Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor

Transgenic mice overexpressing hepatocyte growth factor in the airways show increased susceptibility to lung cancer.

Several studies have suggested a possible role of the hepatocyte growth factor (HGF)/c-Met system in lung tumor development and progression. Extent of expression of both HGF and c-Met have been shown to be negative prognostic indicators of survival and recurrence in non-small-cell lung cancer, especially adenocarcinoma. To further define a role for HGF in lung cancer development and growth, we ...

Breast Cancer Cells Induce Cancer-Associated Fibroblasts to Secrete Hepatocyte Growth Factor to Enhance Breast Tumorigenesis

It has been well documented that microenvironment consisting of stroma affects breast cancer progression. However, the mechanisms by which cancer cells and fibroblasts, the major cell type in stroma, interact with each other during tumor development remains to be elucidated. Here, we show that the human cancer-associated fibroblasts (CAFs) had higher activity in enhancing breast tumorigenecity ...

Hepatocyte Growth Factor Is Positively Associated With Risk of Stroke

The protein hepatocyte growth factor (HGF) and its receptor c-Met are produced in response to tissue injury and are functional in tissue repair mechanisms. Their favorable effects in the heart and vasculature include anti-inflammatory, antifibrotic, and proangiogenic actions. Because HGF is released in response to endothelial injury, higher levels of circulating HGF are associated with hyperten...

Analysis of Soluble Mesenchymal-Epithelial Transition Factor and Hepatocyte Growth Factor Serum Levels in Children With Autism Spectrum Disorder

Background: Hepatocyte Growth Factor (HGF) and its receptor, Mesothelial-Epithelial Transition (cMet) factor signaling, play an essential role in controlling synaptogenesis.  Objectives: Because of the vital role of HGF and Met signaling in synaptogenesis and spatial learning function of the brain’s hippocampal region, we aimed to study the HGF and soluble cMet (s-cMet) serum levels in childre...

Mice Suppresses Collagen-Induced Arthritis in Hepatocyte Growth Factor Significantly